Drostanolone trenbolone enanthate

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Some bodybuilders and athletes use trenbolone esters for their muscle-building and otherwise performance-enhancing effects. [5] Such use is illegal in the United States and many other countries. The DEA classifies trenbolone and its esters as Schedule III controlled substances under the Controlled Substances Act . [18] Trenbolone is classified as a Schedule 4 drug in Canada [19] and a class C drug with no penalty for personal use or possession in the United Kingdom . [20] Use or possession of steroids without a prescription is a crime in Australia . [21] The infamous "duchess" cocktail administered to Russian athletes at the Sochi Winter Olympics consisted of oxandrolone , a metenolone ester, and a trenbolone ester. [22]

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Like other AAS, drostanolone is an agonist of the androgen receptor (AR). [3] It is not a substrate for 5α-reductase and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic to androgenic activity. [3] As a DHT derivative, drostanolone is not a substrate for aromatase and hence cannot be aromatized into estrogenic metabolites . [3] While no data are available on the progestogenic activity of drostanolone, it is thought to have low or no such activity similarly to other DHT derivatives. [3] Since the drug is not 17α-alkylated , it is not known to cause hepatotoxicity . [3]

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Drostanolone trenbolone enanthate

drostanolone trenbolone enanthate

Like other AAS, drostanolone is an agonist of the androgen receptor (AR). [3] It is not a substrate for 5α-reductase and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic to androgenic activity. [3] As a DHT derivative, drostanolone is not a substrate for aromatase and hence cannot be aromatized into estrogenic metabolites . [3] While no data are available on the progestogenic activity of drostanolone, it is thought to have low or no such activity similarly to other DHT derivatives. [3] Since the drug is not 17α-alkylated , it is not known to cause hepatotoxicity . [3]

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